Earlier in the day, the doctors had said that her condition was stable and she might be discharged from hospital in the next two to three days for treatment at home.
However, late in the evening the breathing difficulties of the 82-year-old actress increased along with drop in the oxygen saturation rate, the doctors said.
Sen and her family members, actresses Moon Moon, Riya and Raima, had wished that she should be treated at home now, sources said.
The screen goddess of yesteryears was admitted to the hospital on December 23 following a respiratory tract infection. Later she was treated in a private Intensive Treatment Unit for chronic obstructive pulmonary disease.
Sen, who has been living the life of a recluse in a south Kolkata apartment, has starred in memorable Hindi films like 'Devdas', and 'Aandhi' and 'Saat Paake Bandha', 'Agnipariksha', 'Saptapadi' and 'Deep Jwele Jai' in Bengali.
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