Kabul deputy police chief Mohammad Daoud Amin said the blast was in the Pul-e-Surkh area of the western part of the city, which is miles away from the site of the handover ceremony attended by NATO chief Anders Fogh Rasmussen and Afghan President Hamid Karzai.
A police officer named Asadullah said the target was the convoy of Mohammed Mohaqiq, a prominent ethnic Hazara lawmaker who is a former Cabinet member.
Mohaqiq survived the blast, according to Nahim Lalai Hamidzai, another member of the Afghan parliament.
Gen. Mohammad Zahir, chief of the Kabul Criminal Investigation Division, said three people were killed by the bombing and another 30 were wounded including six bodyguards.
"The roadside bomb targeted the Mohaqiq convoy, but he safely passed. One of his vehicles was damaged," Zahir said.
The leader of the People's Islamic Unity Party of Afghanistan, Mohaqiq is a member of the National Front, which represents members of the former Northern Alliance that fought the Taliban before the US invasion in 2001.
The Taliban insurgency has been pressing an intense campaign of violence in the run-up to today's security handover.
The transition is a major milestone of the 12-year-old war, with the coalition insisting Afghan security forces it has been training for years are now strong enough to take the lead in the fight against the Taliban.
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