Heard will appear alongside Channing Tatum, Matt Bomer, Joe Manganiello and Alex Pettyfer.
Matthew McConaughey is not returning for the sequel, which will follow the lives of a group of male strippers.
Gregory Jacobs is directing from a script co-written by Tatum and Reid Carolin, who penned the first installment.
The first film's director Steven Soderbergh is returning as editor and cinematographer though under his pseudonyms Mary Ann Bernard and Peter Andrews, according to the Hollywood Reporter.
The film is set for a July 1, 2015 release.