On what turned out to be a tough day for the world champion, Caruana did everything right after sacrificing a pawn in the middle game and Anand had little clues to better the judgement of the young Italian genius.
World number one Magnus Carlsen of Norway got off to a flying start defeating arch-rival Vladimir Kramnik of Russia to find himself in early lead in the 10-player round-robin tournament.
With eight rounds still to come in the strongest super-tournament of the year, Mamedyarov, Carlsen and Caruana nosed ahead with victories and the Russian trio of Sergey Karjakin, Dmitry Andreikin and Alexander Morozevich remain closed behind half a point adrift along with Boris Gelfand of Israel.
Anand, Kramnik and Nakamura are at the bottom but the standings are likely to change early as the second round gets underway in no time.
Playing the white side of a Ruy Lopez, Anand was surprised to find Caruana playing one of the topical systems that involves a pawn sacrifice which, once declined, became a topic of discussion in the press room.
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