K Subbalakshmi (25) and her husband K Srinivas (30) married eight years ago. Of late their relations had become strained, police said.
Subbalakhmi was staying at her mother's house for the past few months.
Srinivas visited her many times and asked her to come back, but she refused, police said.
Today, as she stepped out of her mother's house for going to a shop, a waiting Srinivas threw acid on her, police said.
Subbalakshmi, who received burn injuries on face, hands and stomach, was admitted in the Rajahmundry General Hospital.