The Indo-American combine were outplayed by the Uruguayan-Serbian pair of Pablo Cuevas and Viktor Troicki 6-4, 6-3 in just 54 minutes at hard courts of the Beijing Olympic Green Tennis Center.
Bopanna and Isner were broken thrice in the contest, twice in the second set, as they could not keep up with the pace of play of their opponents. The duo had three breakpoint opportunities in the match but all were wasted.
Meanwhile veteran Indian star Leander Paes had already lost his opener with Australia's John Peers on Tuesday when the pair went down to the fourth-seeded Canadian-French pair of Daniel Nestor and Edouard Roger-Vasselin 6-7(1), 6-4, 9-11.
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