"The UK government is driven from the front and we all have the same destination in our sights -- and that is getting a good deal for Brexit with the European Union," she said during a visit to Canada.
Her remarks in Ottawa come after Foreign Secretary Boris Johnson stirred up colleagues and put pressure on May by laying out his own vision for Brexit.
The foreign secretary was accused of "backseat driving" by a fellow minister over his demand for a clean break with the EU.
May said she is seeking with the EU "a good trade deal and (an) ongoing relationship with other matters like security."
Maintaining a "deep and special partnership" with the EU, she added, "is not only in the interest of the United Kingdom but in the interest of the remaining 27 member states of the European Union as well."
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