While Brownstein will play Larry David's constipated employee, the ninth spell also includes Bryan Cranston, Jimmy Kimmel, Nick Offerman and Elizabeth Banks in the guest list, according to Billboard.
Actor Lauren Graham will portray David's new love interest.
"Curb Your Enthusiasm" returns after a six-year-long hiatus.
The series was created by David, who stars as a fictionalised version of himself.
"Curb..." follows the protagonist in his life as a semi- retired television writer and producer in Los Angeles and later New York City.
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