The 61-year-old actor said he loves meeting his fans but signing autographs is one thing he "just can't do anymore".
Cranston, however, said he is open to getting clicked with his fans and is willing to oblige them with their requests.
"Friends, after 18 years of signing everything for fans - I'm retiring. Overwhelmed by requests and I just can't do it anymore," Cranston tweeted.
"I love meeting fans and will personalise pix in person, but that's all. Thanks for your understanding. See you on the street - we'll take a selfie!" he added.
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