Winfrey, 60, and her boyfriend Stedman Graham have been together since 1986 but they never had a child, reported ABC News.
"I could not have had the life or the career in the way that I had it if I'd chosen to have children," Winfrey said.
The TV star, who ended her talk show in 2011, said she does not miss having to do a show every day.
"I don't miss that because you know you're only as good as the last show. You're always chasing the numbers," Winfrey said. "And this is the thing: The 25 years are a blur to me because I just worked."
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