It is the first Academy award win for Afleck, who is better known as the young brother of Oscar winner Ben Affleck. He was earlier nominated for his supporting work in 2007 film "The Assassination of Jesse James".
An emotional Affleck acknowledged fellow nominee Denzel Washington, saying he was the first person to teach him how to act.
"I'm here because of the goodwill of so many people but most importantly Kenneth Lonergan who made this part without which I would not be here. I wish I had something more meaningful to say but I am just happy to be part of this fraternity," Affleck said while also paying tribute to his brother and producer Matt Damon.
Except Gosling, this year's Oscar race for best actor featured performers, who have played troubled protagonists in dramas with heavy themes.
"Manchester" a haunting, intensely powerful film and much of the credit goes to Affleck for playing a depressed Massachusetts janitor coping with the aftermath of an unspeakable tragedy and becoming the guardian of a teenager.
Notably, Affleck's role was passed on by "Manchester" Damon. The film was initialliy conceived of by Damon and co- producer John Krasinski.
Affleck was sued for USD 2 million by one woman and USD 2.25 million by the other. Both cases were settled out of court for an undisclosed amount in 2010.
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