Harriet Wran, 26, was also charged with the attempted murder of a second man and aggravated break and enter. Two men face similar charges.
They are accused of killing Daniel McNulty, 48, who was stabbed at a public housing block in inner-city Redfern on Sunday. A second man was found with multiple stab wounds and is in hospital.
Wran, the goddaughter of late media mogul Kerry Packer, was last in the public eye in May at the state funeral of her father, which was attended by a roll call of heavyweight political figures.
Despite coming from a privileged background, Harriet Wran has been addicted to the drug ice, also known as crystal meth or methamphetamine, for a considerable period of time and was living penniless on the streets, the Australian Broadcasting Corporation said.
Other reports said Wran, a modern history student at the University of Sydney, took the death of her father hard and was allegedly attempting to buy drugs worth USD 65, with the two men also charged, when a fight broke out and McNulty was stabbed.
Her barrister Winston Terracini said outside Liverpool Local Court that his client would fight the charges.
"I've indicated at this stage we'll be pleading not guilty," he said.
Wran's mother Jill flew in from Brisbane but refused to comment, only saying "Please don't" when approached by reporters.
The case was adjourned until October 8.
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