The 43-year-old "Scream" star and his entertainment reporter girlfriend exchanged vows on Sunday during an intimate ceremony in Los Angeles, in front of family and close friends, reported People magazine.
The couple's 11-month-old son Charlie West and Coco, the actor's 10-year-old daughter from his marriage to ex-wife Courteney Cox were part of the nuptials.
Arquette and McLarty have been dating on and off since 2011, and the actor proposed to her in July last year.
He was previously married to "Friends" star Cox for 11 years until they split in 2010.
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