Liverpool appear to have the Premier League title wrapped up with a 13-point advantage over second-placed Leicester but the fight to avoid relegation looks like being a down to the wire tussle.
Just nine points separates ninth-placed Crystal Palace and third from bottom Aston Villa.
Here AFP Sport picks out three pivotal matches in Wednesday's action:
Arteta needs to get Gunners firing ==================================
Hammers pray Moyes delivers in second coming
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"I feel like I've got unfinished business."
Watford's revival faces stern Wolves test =========================================
Pearson for his part will be looking for more of the same of what he witnessed against Villa: "We showed good intensity. We showed incredible unity on the pitch and bench. We have to make sure that remains high on our agenda -- to keep the players together."
Fixtures
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Wednesday (1500 GMT unless stated) Brighton v Chelsea, Burnley v Aston Villa (both 1230), Newcastle v Leicester, Southampton v Tottenham, Watford v Wolverhampton Wanderers, Manchester City v Everton (1730), Norwich City v Crystal Palace (1730), West Ham v Bournemouth (1730), Arsenal v Manchester United (2000)
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