The actors, who star as Dr Watson and Mary in "Sherlock" series, have been together since 2001 and share two children, Joe, 10, and Grace, eight.
"Yes, (it was) so weird. Especially playing new parents again, up all night feeding and things, because we were effectively revisiting how it was when we first got together," Abbington told Stella magazine.
She said while there were "pressure points" during the filming, she would love to work with her ex-partner again in the future.
"Martin and I remain best friends and love each other, and it was entirely amicable, but we realised we'd come to the end of our time together," she said.
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