The incident took place on Friday night near Barton Mills. A man, 77, and a woman, 75, from Ely, Cambridgeshire, and two men, aged 24 and 28, from Mildenhall in Suffolk died at the scene.
It is believed that two vehicles were in collision, one vehicle left the road, ended up in the front garden of a home and caught fire, they said.
Neighbours rushed outside and tried to put the flames out but were unable to contain the fire.
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