Matt Damon, Julianne Moore and Josh Brolin, who all have worked with Coen Brothers in past are in negotiations to lead the project, reported Entertainment Weekly.
The film is a crime noir story set in the '50s.
The movie will mark 54-year-old Oscar winning actor's first outing as director after 2014 film "Monuments Men".
Clooney will also produce with Smokehouse Pictures partner Grant Heslov and Joel Silver of Silver Pictures Entertainment.
Production work on the film will start in October, 2016.
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