Hibernating bears hold key to protect astronauts' bones

Black bears that hibernate for months could hold the key to better bone health for astronauts who undergo long periods of inactivity in space missions, a new study has found.
Even a short period of inactivity can be extremely bad for our bones, and for astronauts facing months in zero gravity, the risks are serious, researchers said.
Black bears routinely hibernate for 6 months without stirring, and although it can take several weeks for them to regain their full metabolic vigour, their bones seem largely unaffected by the lengthy period of inactivity.
Intrigued by bone regeneration, Seth Donahue from Colorado State University and an international team of collaborators decided to monitor the blood levels of specific enzymes and hormones that are known to contribute to bone formation and resorption to find out how bears protect their bones during hibernation.

The team captured 13 female bears over four hibernation seasons, and collected blood and bone samples from the animals before releasing them back into the wild the following spring.
Carefully analysing the blood samples for bone-specific alkaline phosphatase (BSALP) and tartrate-resistant acid phosphatase (TRACP) - which indicate bone rebuilding - the team found that the blood enzyme levels fell in the hibernating bears, suggesting that the hibernating animals were suppressing bone remodelling.

When the team analysed the levels of bone-regenerating osteoblast cells at the surface of the bone, they plummeted from 2 per cent before hibernation to 0.15 per cent during hibernation.

However, the levels of cocaine and amphetamine regulated transcript (CART) - which is known to reduce bone resorption - increased 15-fold during hibernation.
Instead of constantly rebuilding, the bears were protecting their bones by suppressing resorption of the tissue, the study published in the Journal of Experimental Biology found.
The team also found that the bears' blood calcium levels varied little from season to season, suggesting that the animals balance bone resorption and formation during hibernation to maintain stable blood calcium levels, which are also essential for healthy organ function and fat and energy metabolism.
"Hibernating bears are metabolic marvels," said Donahue and his colleagues, adding that these animals appear to be immune to two major epidemics sweeping the world - obesity and inactivity - suggesting that we could learn a thing or two from these creatures.