Duff, 26, finished up the Disney live-action teen sitcom in 2004 after two seasons and a film, reported Huffington Post.
"I would be totally open to it. My schedule is a little busy right now. But um... Why not?" she said.
"I mean, so many people loved her. I loved her. Honestly, working on that show, I got so strong with my physical comedy and all the things that they would throw at me.
"I got covered in goo every week, and I got, like, smashed in the face with a locker every single week. I mean it was a really, really fun show. And obviously people really loved her. Maybe a 'Lizzie: Where Are You Now?', like, ten years later."
The singer has also worked with Ed Sheeran on a track called 'Tattoo'.
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