"A ruptured gas main was discovered using detection equipment and high levels of natural gas were detected in the atmosphere," a London Fire Brigade spokesman said.
"As a precaution, approximately 1,450 people have been evacuated. They are from a hotel and a night club."
Charing Cross and Waterloo East train stations, which brings commuters into the capital, were also closed, while Tube trains were not stopping at Charing Cross.
The Strand, a major road running from Trafalgar Square to Waterloo Bridge, was also closed and people were asked to avoid the area.
A spokesman for the Cadent Gas company said: "We are working with the emergency services and as a safety precaution an exclusion zone has been put in place.
"The Amba Hotel, nearby flats, offices and Charing Cross stations were evacuated.
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