The news was confirmed by the show's network and it is set to premiere in 2016, reported E!Online.
The first series has followed Jenner's transition and adjustment to living life as a transwoman.
It has also centred on her relationship with members of her family and how they reacted to getting to know the person they formerly knew as Bruce.
There has been a particular focus on the relationship between Jenner and her ex-spouse Kris Jenner.
"I Am Cait" has also centred on Jenner becoming an advocate for transgender people.
A representative for E!, Executive Vice President of Programming and Development Jeff Olde, also released a statement.
"Caitlyn's story has ignited a global conversation on the transgender community on a scale that has never been seen before. We are honored Caitlyn has chosen to continue to share her ongoing story with our viewers around the world.
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