The acquisition is by IBM's Watson Health unit, which uses the power of the Watson supercomputer for data analysis in the health industry.
Truven provides analytics for more than 8,500 clients in the public and private sectors and impacts the health benefits of one out of three Americans, according to the two companies.
The Truven deal adds to Watson Health's takeovers of health management software firm Phytel and the Explorys healthcare database in 2015.
With the purchase of Truven, the company has spent more than USD 4 billion to acquire and build healthcare capabilities.
After the Truven deal is completed, IBM said, its health cloud business "will house one of the world's largest and most diverse collections of health-related data, representing an aggregate of approximately 300 million patient lives acquired from three companies."
IBM shares were up 4.3 percent to $131.41 in opening trade after the announcement.
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