"We see the uncertainty right now as probably the biggest risk to the global economy," said IMF spokesman Gerry Rice, calling on European leaders and other policymakers to take "decisive" actions that could lower the threat.
The European Union and Britain face negotiations on the Brexit that are expected to be difficult and protracted.
European Union leaders say that until Britain formally begins exit proceedings, no talks can begin - formally or informally - on resetting Britain's ties with the EU, a process meant to last two years.
"Brexit has created significant uncertainty and we believe this is likely to dampen growth in the near term, particularly in the UK but with repercussions also for Europe and for the world economy," said Rice in a regularly scheduled IMF news conference.
"We need to be ready, all of us policymakers, with decisive actions that can help mitigate that as much as possible.
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