Mohammed Javad Zarif is quoted by the website of Iranian state TV today as saying the letter by 47 GOP senators was "unprecedented and undiplomatic." He had earlier dismissed the letter as a "propaganda ploy."
The White House and Democrats in Congress also denounced the letter, accusing the senators of trying to sabotage the negotiations.
The United States, along with five world powers, hopes to negotiate a framework agreement this month and a final accord later this year which would curb Iran's nuclear program in exchange for sanctions relief.
