"50 First Dates" director Peter Segal will helm the film, which follows a big-box store employee who, after reinventing herself, gets the chance to prove to Madison Avenue that street smarts are as valuable as a college degree, according to The Hollywood Reporter.
The script has been written by Justin Zackham and Elaine Goldsmith-Thomas.
"There are so many things I love about this project and script. People try to put women to sleep at a certain age. 'Second Act' is a story that empowers the every-woman to do more, to be more, and not limit their dreams," said Lopez.
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