Depp performed with his close friend Steven Tyler and the rest of the rockers at their show on Wednesday, reported People magazine.
"He played guitar on the encore," one from the audience said. Dressed casually in jeans and a black knit cap, Depp played 'Train Kept a Rollin' with the band.
Depp is in Boston to wrap up filming 'Black Mass', the story of notorious gangster Whitey Bulger.
On Monday, he was spotted shooting scenes with costar Sienna Miller, who plays Bulger's longtime girlfriend Catherine Grieg.
Depp and Tylor share a mutual admiration for each other and often jam together. The actor also based his character of Jack Sparrow in 'Pirates of the Caribbean' on the rocker.
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