The 57-year-old actor was nominated in the Outstanding Performance by a Female Actor in a Comedy Series category for her role in "Veep".
Louis-Dreyfus, who was diagnosed with breast cancer last year, gave a miss to the ceremony and thanked the guild for the award on Twitter.
"I wish I could have been @SAGawards tonight but have to admit it's pretty fun to watch in my pj's. So honored to win," she wrote.
The actor won another SAG at the event as the HBO series bagged the honour of Outstanding Performance by an Ensemble in a Comedy Series.
Her twin win at the 24th annual awards ceremony brought the actor's award tally to a total of nine, making her the artiste to have the highest SAGs till date.
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