Karen will play Martha, whose character details have yet to be released, while Nick, who was in talks to star in the film last month, will reportedly play Alex, reported Deadline.
Dwayne Johnson, Kevin Hart, and Jack Black will also star in the latest version of the beloved 1995 film, about a boy who becomes trapped in a magical board game.
Johnson has now taken to Instagram to welcome Karen to the cast.
"This isn't just any role, but in many ways the most important role of the movie. We had to find a girl. But not just any girl," he wrote.
"Ladies and gentlemen, I'm proud to announce a girl who's playing the most important role in our movie - the talented, beautiful and down for a Scottish fight at any time, Ms @KarenGillanOfficial...," he added.
The film is being directed by Jake Kasdan and production is slated to begin next month in Honolulu, Hawaii. The film is set to be released in July, 2017.
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