The 21-year-old stunner was spotted hanging out with the pro-baller and his friends at New York City hot spot Beauty & Essex, reported Ace Showbiz.
A source said Upton met Griffin, who was with a group of friends which included Beauty & Essex staffers, just before midnight, engaging in chit-chat over Mexican food and tequila shots.
The two were reportedly "cuddling and holding hands" and appeared "very cozy" with each other, although they were not seen making out.