The Sports Illustrated model is in talks with casting directors over a potential role in the movie, reported Ace Showbiz.
Upton has not been offered the role officially yet, however talks between the actress and Warner Bros are believed to be in the advanced stages.
The details of the models' potential role have been kept under wraps for now, although it is believed that she may portray the latest love interest of movie star Vincent Chase (Adrian Grenier).
Should Upton be appointed in the film, she will be joining returning stars Adrian Grenier, Kevin Connolly, Kevin Dillon, Jerry Ferrara and Jeremy Piven, who have all agreed to reprise their roles from the hit HBO series.
Filming is due to get underway early next year and the film is scheduled for a 2015 release.
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