Kulsoom was diagnosed with early-stage throat cancer last month and has been in London since, where she has undergone three surgeries. On Tuesday, she was readmitted to a hospital after her condition deteriorated. She has now been discharged.
Her daughter, Maryam Nawaz, who is in London, tweeted, "Ami is better, discharged from the hospital & back home."
"Her further treatment including chemotherapy starts next week," she said.
Kulsoom recently won Lahore's NA-120 seat vacated by Nawaz Sharif after he was disqualified by the Supreme Court in the Panama Papers case.
Quoting doctors, the Sharif family had said that Kulsoom's cancer was curable.
Sharif, who was also in London for his wife's treatment, returned to Pakistan on Monday, putting to rest speculation that he would skip the corruption cases against him.
All other members of the family, including daughter Maryam and sons Hussain and Hassan, are still in London.
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