A meta-analysis of structural MRI volumes at Rosalind Franklin University of Medicine and Science found no significant difference in hippocampal size between men and women.
Meta-analysis is a statistical technique that allows researchers to combine the findings from many independent studies into a comprehensive review.
The team headed by Lise Eliot, associate professor of neuroscience at the university's medical school, examined findings from 76 published papers, involving more than 6,000 healthy individuals.
"They often make a big splash, in spite of being based on small samples. But as we explore multiple datasets and are able to coalesce very large samples of males and females, we find these differences often disappear or are trivial," Eliot said.
Hippocampi are located on both sides of the brain, under the cerebral cortex. The team's findings challenge the common claim that a disproportionately larger hippocampus explains females' tendency toward greater emotional expressiveness, stronger interpersonal skills, and better verbal memory.
Meta-analyses by other investigators have also disproved other purported sex differences in the brain, Eliot noted.
There is no difference in the size of the corpus callosum, white matter that allows the two sides of the brain to communicate, nor do men and women differ in the way their left and right hemispheres process language, Eliot said.
The study appears in the journal NeuroImage.
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