The 62-year-old 'My Kind of People' star said he feels better now, but was once in the clutches of alcohol addiction and depression, reported Daily Star.
"I've been taken off to the hospital a couple of times. Too many pills, just chuck a load in my mouth. I think that was a cry for help," he said on a television chat show.
Barrymore did not specify when the suicide attempts took place but assured his depression is not currently as severe.
"I'm a good boy now. I'm obviously not successful at it because I'm here," he said.
"When you're in the depths and the throes of your depression and your addiction, I end up in the corner of the room staring at the wall. And it doesn't matter how big the house is or how small the flat is, you end up in exactly the same spot thinking 'What's the point?'" he said.
