World no 150 Mouma's challenge was lukewarm and short-lived as the Indian veteran, in her second Olympics, lost to world No 58 Daniela Dodean Monteiro of Romania 2-11, 7-11, 7-11, 3-11.
Debutant Manika, on the other hand, put up a good fight before going down to her 60th-ranked Polish rival Katarzyna Franc-Grzybowska 2-4 (12-10 6-11 12-14 11-8 4-11 12-14 in 48 minutes in another preliminary round clash.
In the men's singles, Sharath Kamal and Soumyajit Ghosh will play their first round matches later in the day.
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