"Make no mistake -- any attack on the United States or our allies will be defeated," he said at a press conference on his trip to Seoul.
"Any use of nuclear weapons by the North will be met with a massive military response, effective and overwhelming."
Tensions have been running high on the Korean peninsula, with the North conducting its sixth nuclear test last month and test-launching multiple missiles capable of reaching the US mainland.
The North's ruler Kim Jong-Un and US President Donald Trump have also traded verbal threats of war and personal insults that have sparked global alarm.
He urged Pyongyang to "harbour no illusion", saying the isolated state is militarily "overmatched" by the US and South Korea -- a key ally of Washington that hosts 28,500 US troops.
Trump's recent remark that "only one thing will work" with the North fuelled concerns of a potential conflict on the divided peninsula where the 1950-53 Korean War had left millions dead.
But even some Trump advisers say US military options are limited when Pyongyang could launch an artillery barrage on the South's capital Seoul -- only about 50 kms from the border and home to 10 million people.
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