The study in the journal Environmental Science and Technology Letters tested more than 400 samples from 27 fast food chains in the US.
Almost half of paper wrappers and 20 percent of paperboard samples -- such as boxes for fries and pizza -- contained fluorine, a marker for highly fluorinated chemicals used in stain-resistant carpets, non-stick cookware and waterproof outdoor apparel.
"Wrappers for Tex-Mex food, desserts and breads were the most likely to contain fluorine," said the report.
But researchers warned that exposure to some PFASs has been associated with cancer, thyroid disease, immune suppression, low birth weight, and decreased fertility according to prior studies.
"These chemicals have been linked with numerous health problems, so it's concerning that people are potentially exposed to them in food," said lead author Laurel Schaider, an environmental chemist at the Silent Spring Institute.
"Children are especially at risk for health effects because their developing bodies are more vulnerable to toxic chemicals."
Researchers also detected some shorter-chain PFAS compounds, which have been increasingly used as replacements for the longer chain PFASs.
"The replacement compounds are equally persistent and have not been shown to be safe for human health," said co-author Arlene Blum, founder of the Green Science Policy Institute.
"That's why we need to reduce the use of the entire class of highly fluorinated compounds. The good news is there are non-fluorinated alternatives available."
The United States began phasing out certain PFASs in 2000, but other countries still produce them, and they tend to linger in the environment for long periods after being discarded in landfills.
Prior studies have shown that substances in food packaging can migrate into food.
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