"Obama-Clinton have single-handedly destabilised the Middle East, handed Iraq, Libya and Syria to ISIS, and allowed our personnel to be slaughtered at Benghazi. Then they put Iran on the path to nuclear weapons," Trump, the Republican presidential nominee said in a statement.
Trump's remarks came after Obama at a White House news conference said the Republican nominee is unfit to serve as president.
Trump in a hard hitting statement alleged that the Obama-Clintonduo allowed dozens of veterans to die waiting for medical care that never came.
Trump said Clinton, the Democratic presidential nominee, put the whole country at risk with her illegal email server, deleted evidence of her crime, and lied repeatedly about her conduct which endangered Americans.
"They released criminal aliens into our country who killed one innocent American after another -- like Sarah Root and Kate Steinle -- and have repeatedly admitted migrants later implicated in terrorism. They have produced the worst recovery since the Great Depression," he said.
"They have shipped millions of our best jobs overseas to appease their global special interests. They have betrayed our security and our workers, and Hillary Clinton has proven herself unfit to serve in any government office," Trump said.