The couple, who has a two-year-old son, took some time to come to terms with the news, reported E! Online.
"You know we've been trying to get pregnant, hoping to give Duke a sibling and have another child. Sadly, we found out pretty recently that our attempts to get pregnant a second time didn't work out," Rancic said.
The 'Fashion Police' host said that the In vitro fertilisation (IVF) was successful but the surrogate miscarried after nine weeks.
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