The actress plays Special Agent Avery Ryan, who heads up the FBI's Cyber Crime Division that forms the basis for 'CSI: Cyber', according to Entertainment Weekly.
Arquette's character will be reintroduced in CSI on November 2, following a stint in season 14.
The spin-off will be led by Arquette, with Peter MacNicol and James van der Beek among the cast.
It will be the first CSI series to have a female lead and is inspired by Irish Cyber Psychologist Mary Aiken, who will be an executive producer.
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