The Cincinnati Fire Department says the bridge was undergoing demolition at the time of the collapse.
The Cincinnati Enquirer reports that according to a police dispatch the southbound Interstate 75 was closed indefinitely after the collapse of the overpass.
It happened at about 10:30 pm yesterday. The newspaper reports at least one tractor trailer was damaged by the collapse.
Fire and Emergency Medical Service officials say one construction worker was killed and a tractor trailer driver was injured.
A witness told WLWT5 that he heard "a real big boom" and then a couple of seconds later he saw police cars rushing to the scene.
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