"The early morning news from #GreatBritain are truly sobering. It looks like a sad day for #Europe +the #UnitedKingdom," Steinmeier wrote on Twitter.
EU Parliament President Martin Schulz said he would speak with German Chancellor Angela Merkel "on how we can avoid a chain reaction" of other EU states following.
"The chain reaction that is being celebrated everywhere now by euroskeptics won't happen," he said.
The EU was the biggest single market in the world and "Great Britain has just cut its ties with that market," Schulz said.
"I am not shocked," he said of the results of the British referendum, adding: "We were prepared.
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