World No. 2 Saina brushed aside young Riya Mukherjee 21-5 21-13 in the women's singles while World No. 4 Srikanth saw off Thailand's Tanongsak Saensomboonsuk 21-17 21-16 without much ado in the opening round of the men's singles main draw at the Siri Fort Sports Complex.
All England finalist Saina will next take on compatriot Ruthvika Shivani Gadde, who beat qualifier Rucha Nikam 21-7 21-6.
However, it was Sameer, brother of 2011 National Champion Sourab Verma, who notched up a stunning 21-15 21-17 win over Denmark's Hans-Kristian, seeded fifth, to set up a match with Commonwealth Games bronze medallist RMV Gurusaidutt.
Guru prevailed over Korea's Lee Dong Keun 21-14 17-21 23-21 in another match.
Among other Indians in fray, Indonesia Masters winner H S Prannoy set up a clash with world No. 2 Jan Jorgensen of Denmark after beating Misha Zilberman of Israel 22-20 21-8.
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