In men's singles, India's Kidambi Srikanth and Sameer Verma made the second round with contrasting victories, but it was curtains for qualifier R M V Gurusaidutt as he failed to cross the first round hurdle.
Saina, who had won the Australian Open title in 2014, hardly broke a sweat in her opening round game as she outplayed Joy Lai of Australia with a dominating 21-10 21-14 win in just 29 minutes.
However, World No. 10 Sindhu was stunned by South Korea's Kim Hyo Min, ranked 40th in the world, 15-21 19-21 after a 55-minute battle.
But youngster Tanvi Lad registered a come-from-behind win 18-21 21-14 21-11 over qualifier Tiffany Ho of Australia in 52 minutes to enter round two of the tournament.
She will next take on fourth-seeded Wang Yihan.
Srikanth, ranked 12th, posted an easy 21-16 21-12 win over World No.11 NG Ka Long Angus of Hong Kong in a match that lasted 32 minutes, while Sameer had to sweat it out before prevailing over Indonesia's Ihsan Maulana Mustofa 22-20 15-21 21-15 in a 53-minute contest.
Srikanth will next face Indonesia's Sony Dwi Kuncoro, while Sameer will take on the winner of match between Anthony Sinisuka Ginting and Chou Tien-chen.
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