Saina, who is the defending champion and top seed here, took exactly half an hour to get the better of Nedelcheva 21-15 21-10 in the pre-quarterfinals of the women's singles event late last night.
By virtue of this win, Saina, who reclaimed World No 2 position yesterday, took a 6-2 head-to-head lead over 23rd ranked Nedelcheva.
Saina will next face sixth seeded Tzu Ying Tai of Chinese Taipei in the quarterfinal later today.
Rising star P V Sindhu made an exit from the tournament after losing to qualifier Yui Hashimito of Japan 21-23 11-21 in a second round contest of the women's singles event.
London Olympics quarterfinalist Parupalli Kashyap also crashed out in the pre-quarterfinals of the men's singles event after losing to Wei Feng Chong of Malaysia yesterday.
The fifth seeded Indian squandered a game advantage to lose to his ninth-seeded opponent 21-18 7-21 16-21 in a 55-minute contest.
In another men's singles pre-quarterfinal match, H S Prannoy lost to Tien Chen Chou of Chinese Taipei 16-21 21-15 15-21 in an hour's contest.
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