The actor played the pyrokinetic Liz Sherman in Guillermo del Toro's "Hellboy" and "Hellboy II: The Golden Army", that had Ron Perlman essaying the titular character.
"God, you know, people are fans of Hellboy and also fans of Guillermo," Blair told CinemaBlend.
"So part of us, the ones that were so loyal to Guillermo, our hearts are broken that it didn't work out with the greatest third instalment ever written that I wish I could play more than anything in the world," she added.
The reboot has been titled "Hellboy: Rise of the Blood Queen" and will have "Stranger Things" star David Harbour in the titular role.
Blair also hoped that the reboot does justice to the "vision" of Mike Mignola on whose comics the new film is based on.
"I truly hope that Mike Mignola has his vision out there for the darker Hellboy come to light, and I'm sure he will, and David Harbour is excellent and everyone involved, but no my heart is broken," Blair said.
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