The 30-share barometer hit psychological 22,000 mark for the first time and moved up for a brief period to touch a new record high of 22,005.54. The Sensex, however, slid afterwards to trade 47.30 points lower at 21,872.49 in early trade.
Stocks of metal, IT, healthcare and auto sectors led the fall.
Similarly, the National Stock Exchange index Nifty, after soaring to a life-time high of 6,548.75 at the outset, succumbed to profit-booking and slipped 39.30 points, or 0.60 per cent, to 6,487.35.
Among other Asian markets, Hong Kong's Hang Seng fell by 1.42 per cent, while Japan's Nikkei shed one per cent in early trade.
