But Bangladesh, outplayed in two Tests against the hosts, will have to contend with a South African team strengthened by the inclusion of AB de Villiers, one of the world's most dazzling limited-overs batsmen.
Also back in international action for South Africa is JP Duminy, who retired from Test cricket after a run of low scores, but who remains a highly effective one-day player.
In the most recent one-day outings for both teams, Bangladesh reached the semi-finals of the ICC Champions League in England in June, while South Africa failed to advance beyond the group stage.
But the hosts will start strong favourites.
South Africa have won 14 of 17 one-day matches against Bangladesh and triumphed in all six previous encounters in South Africa by convincing margins.
Bangladesh will be under new leadership with veteran bowler Mashrafe Mortaza captaining the side instead of Mushfiqur Rahim, who remains in the squad.
Although Shakib's return from a brief sabbatical will strengthen the tourists, they still rely mainly on the players who suffered two crushing Test defeats.
For South Africa, the series is the first step on a road to the 2019 World Cup.
Faf du Plessis has replaced De Villiers as the one-day captain and together with new coach Ottis Gibson will be seeking to build a squad capable of challenging for global honours.
West Indian Gibson said the intention was to give opportunities over the next year to a large number of players, effectively serving notice to players currently in the squad that they need to perform to remain in the mix.
South Africa: Faf du Plessis (capt), Hashim Amla, Temba Bavuma, Farhaan Behardien, Quinton de Kock (wkt), AB de Villiers, JP Duminy, Imran Tahir, David Miller, Wayne Parnell, Dane Paterson, Andile Phehlukwayo, Dwaine Pretorius, Kagiso Rabada
Coach: Ottis Gibson (WIS)
Bangladesh: Mashrafe Mortaza (capt), Imrul Kayes, Liton Das (wkt), Mahmudullah, Mehidy Hasan, Mohammad Saifuddin, Mominul Haque, Mushfiqur Rahim (wkt), Mustafizur Rahman, Nasir Hossain, Rubel Hossain, Sabbir Rahman, Shakib Al Hasan, Soumya Sarkar, Tamim Iqbal, Taskin Ahmed.
Coach: Chandika Hathurusingha (SRI)
ODI FIXTURES
Oct 15: Kimberley
Oct 18: Paarl
Oct 22: East London.
Disclaimer: No Business Standard Journalist was involved in creation of this content
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