Researchers from Thomas Jefferson University in the US observed about 14 participants ranging in age from 24 to 76.
They attended an retreat based on the spiritual exercises developed by St Ignatius Loyola who founded the Jesuits.
Following a morning mass, participants spent most of the day in silent contemplation, prayer and reflection and attended a daily meeting with a spiritual director for guidance and insights.
After returning, study subjects also completed a number of surveys which showed marked improvements in their perceived physical health, tension and fatigue.
The post-retreat scans revealed decreases in dopamine transporter (5-8 per cent) and serotonin transporter (6.5 per cent) binding, which could make more of the neurotransmitters available to the brain.
This is associated with positive emotions and spiritual feelings. In particular, dopamine is responsible for mediating cognition, emotion and movement, while serotonin is involved in emotional regulation and mood, researchers said.
"Since serotonin and dopamine are part of the reward and emotional systems of the brain, it helps us understand why these practices result in powerful, positive emotional experiences," said Andrew Newberg of Thomas Jefferson University.
The study was published in the journal Religion, Brain & Behaviour.
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