The 55-year-old has revealed that he is suffering from the neurodegenerative disease, according to The Hollywood Reporter.
"I wanted people to hear directly from me that I have been diagnosed with ALS," said Hillenburg in a statement.
He added he has no plans of taking a break from his role on the series.
"Anyone who knows me knows that I will continue to work on SpongeBob SquarePants and my other passions for as long as I am able. My family and I are grateful for the outpouring of love and support. We ask that our sincere request for privacy be honoured during this time," continued Hillenburg.
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