The epicentre of the quake was near the coast, about 93 kilometres northwest of Coquimbo, said the US Geological Survey (USGS). It initially gave the magnitude as 6.6.
The Pacific Tsunami Warning Centre said there was no tsunami threat from the quake, which struck at 8:54 pm (0154 GMT Wednesday) at a depth of 10 kilometres.
Chile's National Emergency Office said there were no reports of harm to people or any disruption to basic services or infrastructure.
Images on Chilean television showed empty streets in La Serena. No damage to buildings or houses were reported and traffic remained normal.
Less than an hour later, a 6.8-magnitude aftershock rattled the same region.
Also centered off the coast some 97 kilometers west-northwest of Coquimbo, it hit at 0246 GMT Wednesday, again at a depth of 10 kilometers.
Chile is no stranger to earthquakes.
In September, the same area of the country was hit by an 8.3-magnitude earthquake and tsunami that left 15 dead and over 16,000 homeless.
Chile lies on what is known as the "Ring of Fire" -- an arc of fault lines that circles the Pacific Basin and is prone to frequent earthquakes and volcanic eruptions.
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